Regioselective Ethanolamination and Ketalization of 3-Ph-2,4-diacetyl(diethoxycarbonyl)-5-hydroxy-5-methylcyclohexanones
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چکیده
منابع مشابه
Novel and efficient regioselective enzymatic approach to 3’-, 5’- and 3’,5’-di-O-crotonyl 2’-deoxynucleoside derivatives
Regioselective syntheses of several O-crotonyl 2’-deoxynucleoside derivatives have been efficiently achieved using a biocatalytic methodology. While Candida antarctica lipase B (CAL-B) afforded the 5’-O-acylated compounds, immobilized lipase from Pseudomonas cepacia (PSL-C) provided the 3’-O-crotonylated analogues. Since classical chemical approaches did not work appropriately due to side isome...
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Synthetic routes toward new 5-amino- and 5-hydroxy-3,3-difluoropiperidines, which are of high interest as building blocks in medicinal chemistry, are described. The key step involves the N-halosuccinimide-induced cyclization of 2,2-difluoro-4-pentenylamines toward 5-halo-3,3-difluoropiperidines, which were used to synthesize 5-amino-3,3-difluoropiperidine. In a second strategy, iodolactonizatio...
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A direct radioimmunoassay of the methyl ester of urinary and serum 5-hydroxy-3-indole acetic acid is described. The antiserum, raised in a rabbit against a conjugate of bovine serum albumin with 5-hydroxytryptamine hemisuccinamide, contained two antigenic fractions, one binding N-acyl 5-hydroxytryptamine, and the other binding methyl ester of 5-hydroxy-3-indole acetic acid, and N-acyl 5-hydroxy...
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The chemistry of natural nucleosides and their analogues has been widely studied due to their potential as fungicidal, antitumor, and antiviral agents. 1 Consequently, extensive modifications have been made to both the heterocyclic base and the sugar moiety in order to avoid the drawbacks shown by nucleosides or analogues in certain applications. For organic chemists, enzymatic-catalyzed reacti...
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tissues such as adrenal, ovary, testis, and placenta. 3b-Hydroxy-D-steroid dehydrogenase is an imIt is a microsomal NAD-dependent enzyme that catportant enzyme of steroid hormone biosynthesis alyzes the conversion of pregnenolone to progesterpresent in steroidogenic tissues like adrenal, testis, one, a rate-limiting step in the biosynthesis of horand ovary of vertebrates. The enzyme is assayed ...
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ژورنال
عنوان ژورنال: Molecules
سال: 2003
ISSN: 1420-3049
DOI: 10.3390/80200251